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CILIDIN
Composition Cilnidipine 5,10 and 20 mg Tablets.
Indication Stage I Hypertension
Mechanism of Action

Cilnidipine is a dihydropyridine calcium-channel blocker. It inhibits cellular influx of calcium, thus causing vasodilatation. It has greater selectivity for vascular smooth muscle. It has little or no action at the SA or AV nodes and -ve inotropic activity is rarely seen at therapeutic doses.

Pharmacokinetic's

Rapid absorption. Cmax within 2 h. Highest level in the liver and also distribution in the kidneys, plasma, and other tissues. No tissue showed a particularly high accumulation of the drug following repeated oral administrations. Protein binding 98% The percentage urinary excretion of benidipine following an oral dose is about 36%

Side effects

Dizziness; flushing; headache; hypotension; peripheral oedema; tachycardia; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression; ischaemic chest pain; cerebral or myocardial ischaemia; transient blindness; rashes; fever; abnormal liver function; gingival hyperplasia; myalgia; tremor; impotence.

Precaution

Hypotension, poor cardiac reserve, heart failure. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischemic pain following administration. Pregnancy, lactation.

Dosage

Oral

Hypertension

Adult: 5-10 mg once daily, increase to 20 mg once daily if necessary.

Child: 6-16 yr 35 kg: 10 mg once daily; ≥35 kg: 20 mg once daily. Doses may be doubled once if necessary after 2 wk. Elderly: No dosage adjustment needed.

Renal impairment: Mild to moderate (CrCl: 20-60 mL/min): Max: 20 mg once daily.

Hepatic impairment: Moderate: Initial: 10 mg once daily may increase up to max 20 mg once daily.

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