|Composition||Nikorandil 5 and 10mg tablets|
|Mechanism of Action||
Nicorandil dilates arterioles and large coronary arteries by opening the potassium channels, and stimulates guanylatecyclase causing venous vasodilatation. It therefore reduces preload and afterload, and improves coronary blood flow.
Absorption: Absorbed well from the GI tract (oral); peak plasma concentrations after 30-60 min.
Distribution: Protein-binding: Slightly bound. Metabolism: Denitration. Excretion: Via urine (as metabolites); 1 hr (elimination half-life)
Headache (usually transitory), flushing, dizziness, nausea, vomiting and weakness. Hypotension and reflex tachycardia at high doses.
Hypovolaemia, low systolic BP, acute pulmonary oedema, pregnancy. May impair ability to drive or operate machinery
Adult: 10 mg twice a day, increase if necessary. Usual dose: 10-20 mg twice a day. May use 5 mg twice a day for patients prone to headache. Max dose: 30 mg twice a day.
Hepatic impairment: Dose reduction may be necessary.