Composition Pantoprazole 40mg Tablet
Indication Co-Rx with NSAID, GERD, Gastric ulcer
Mechanism of Action

Pantoprazole sodium is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of anti-secretory effect that persists longer than 24 hours for all doses tested


Absorption After administration of a single or multiple oral 40 mg doses of Pantoprazole Sodium Delayed-Release Tablets, the peak plasma concentration of Pantoprazole sodium was achieved in approximately 2.5 hours, and Cmax was 2.5 µg/mL.

Distribution The apparent volume of distribution of Pantoprazole sodium is approximately 11.0–23.6 L, distributing mainly in extracellular fluid. The serum protein binding of Pantoprazole sodium is about 98%, primarily to albumin.

Metabolism Pantoprazole sodium is extensively metabolized in the liver through the cytochrome P450 (CYP) system. Pantoprazole sodium metabolism is independent of the route of administration (intravenous or oral). The main metabolic pathway is demethylation, by CYP2C19, with subsequent sulfation; other metabolic pathways include oxidation by CYP3A4. There is no evidence that any of the Pantoprazole sodium metabolites have significant pharmacologic activity.

Elimination After a single oral or intravenous dose of 14C-labeled Pantoprazole sodium to healthy, normal metabolizer volunteers, approximately 71% of the dose was excreted in the urine, with 18% excreted in the faeces through biliary excretion. There was no renal excretion of unchanged Pantoprazole sodium.

Side effects

Abdominal or stomach pain

blurred vision

dry mouth

flushed, dry skin

fruit-like breath odour


This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are taking this medicine for more than one year, or if you are taking this medicine together with digoxin or certain diuretics or "water pills". Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness.


Orally once a day